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                Recombinant human CTLA4(10ug)

                簡要描述:Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa.

                • 產品型號:abs02003
                • 廠商性質:生產廠家
                • 更新時間:2025-02-07
                • 訪  問  量:1610

                詳細介紹

                品牌absinCAS-
                分子式-純度-
                分子量-貨號abs02003
                規格10ug;100ug供貨周期現貨
                主要用途-應用領域生物產業

                描述:

                Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa. Purified CTLA4 protein is below the position of 26 kDa on SDS-PAGE gel under reduced condition.
                CTLA4 protein is purified by proprietary chromatographic techniques. 


                Entrez Gene summary for CTLA4:

                This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.


                UniProtKB/Swiss-Prot: P16410 (CTLA4_HUMAN)

                Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.


                別名:

                Cytotoxic T-lymphocyte 4蛋白;Cytotoxic T-lymphocyte protein 4 / CTLA4


                來源:

                Mammalian cells


                形態:

                Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5


                儲存/保存方法:

                Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.


                Accession:

                NP_005205.2

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